Author: Prof. Wenle Zhao

Better alternatives to permuted block randomization for clinical trials with unequal allocation

Prof. Wenle Zhao 2016-10-14 No Comments 33 views

Meurer, Connor, and Glassberg published ‘Simulation of various randomization strategies for a clinical trial in sickle cell disease’, proposing a biased-coin adaptive randomization design for a trial with a small sample size of 45 and an unequal target allocation of 1:2 between placebo and active treatment, and compared it with the complete randomization and the permuted block randomization via co...

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Better alternatives to permuted block randomization for clinical trials with unequal allocation

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